Friday, March 17, 2006

Origin and funding of the most frequently cited papers in medicine: database analysis -- Patsopoulos et al., 10.1136/bmj.38768.420139.80 -- BMJ

Origin and funding of the most frequently cited papers in medicine: database analysis -- Patsopoulos et al., 10.1136/bmj.38768.420139.80 -- BMJ
(recommended by Marcelo Gustavo Colominas [mgcolominas@gigared.com])
Results Of the 289 frequently cited articles, most had at least one author with a university (76%) or hospital (57%) affiliation, and the proportion of articles with each type of affiliation was constant over time. Government or public funding was most common (60% of articles), followed by industry (36%). The
proportion of most frequently cited articles funded by industry increased over time (odds ratio 1.17 per year, P = 0.001) and was equal to the proportion funded by government or public sources by 2001. 65 of the 77 most cited randomised controlled trials received funding from industry, and the proportion
increased significantly over time (odds ratio 1.59 per year, P = 0.003). 18 of the 32 most cited trials published after 1999 were funded by industry alone.
Conclusion Academic affiliations remain prominent among the authors of the most frequently cited medical research. Such research is increasingly funded by industry, often exclusively so.
Academics may be losing control of the clinical research agenda.

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